Genomic Mid-Range Inhomogeneity (MRI) is the notion that nucleotides are related to one another over distances greater than the oligonucleotide level but less than at the isochore level.  Specifically, we have observed these relationships at a range of 30-1000 nucleotides.

     In order to isolate the effects of these relationships from the many forms of Short-Range Inhomogeneity (SRI), one can compare the properties of a natural sequence with the properties of a random sequence with the same oligonucleotide composition.  This site contains a set of tools to enable any researcher to do exactly that.

     SRI analyzer profiles the oligonucleotide composition of a FASTA-formatted file containing RNA/DNA sequences.  SRI generator uses that composition profile to generate randomized sequences matching the dimensions of a given file.  MRI analyzer searches real or random sequence files for regions of mid-range inhomogeneity.  Finally, MRI visualizer allows one to visualize the distribution of these regions on the concatenated sequence. See the How-to/README page for a more detailed outline of these tools.

     Click the button below to start a new session or to resume a prior session.